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Orexin and Sleep: Molecular, Functional and Clinical Aspects
Dissociating orexin-dependent and -independent functions of orexin
To Eat or to Sleep? Orexin in the Regulation of Feeding and
Understanding the Role of Orexin in Sleep and Wakefulness - Takeda
Orexin and Psychoneurobiology: A Hidden Treasure IntechOpen
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Jan 5, 2016 in the brain, the levels of the high energy molecule, adenosine orexin is important for both sleep-wake regulation as well as feeding and energy balance. Mainly ghrelin, secreted by the stomach has an opposite func.
Jun 4, 2019 focusing on sleep/wakefulness, we also manipulated orexin neuronal to visualize the function of flp recombinase, we bred these mice with gene product, c-fos, which is a surrogate molecular marker of neuronal activi.
The potential executive function of orexin in coordinating the known hypothalamic narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Oct 26, 2019 krithika subramanian, phd discusses the orexin receptor pathway, and multifaceted functional significance of this neuropeptide/receptor narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Mar 17, 2009 oxgko mice exhibit severe fragmentation of sleep/wake states mice selectively lacking functional gabab receptors in orexin neurons.
Orexin-a binds to both ox1r and ox2r with a high affinity, whereas orexin-b binds only to ox2r with a similar high affinity molecular function, neuropeptide.
Feb 18, 2021 activity of orexin in the regulation of sleep ⁄ wakefulness in vivo.
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Oct 1, 2007 at least one of the hcrt peptides was found to be neuroexcitatory to hypothalamic cells but its precise function was not known.
Nov 10, 2020 there's an exciting research program looking at medicines that boost the activity of hypocretin/orexin in the brain.
Oct 5, 2014 play a role in the homeostatic regulation of sleep. However, the molecular function and dynamics of gabaars on identified orexin neurons.
Questions of sleep circuitry and sleep function on a molecular level. As genetic tools projection pattern of orexin neurons and the localization of the fish orexin.
Agonists of the orexin receptor 2 (ox2r) show promise in the treatment of a small-molecule agonist suggest a molecular mechanism that rationalizes both and involved in different brain circuits that orchestrate sleep and wakefulnes.
Furthermore, orexin agonist like modafinil ameliorates cognitive function, attention, and antipsychotic-induced.
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